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The effective use of neoepitope-based vaccines in personalized cancer immunotherapy

Publication: STEM Fellowship Journal
5 January 2023

Abstract

In an era where modern medicine has increased the duration and quality of life, cancer remains one of the world’s leading causes of death [1]. As cancer is characterized by random and somatic mutations within each tumour’s specific genome, personalized immunotherapies have become increasingly popular as potential courses of treatment [2-6]. Notably, therapeutic neoepitope-based vaccines have been shown to elicit potent, T-cell-mediated antitumour activity in numerous clinical and preclinical models. As an immunotherapy, neoepitope vaccination harnesses the immune system’s specificity to target tumour-specific markers present on cancer cells [2]. Thus, neoepitope vaccines represent a new frontier in personalized cancer treatment [2]. Although challenges remain in the development and administration of neoepitope vaccines, the technology shows incredible promise and merits further research. The following viewpoint will explore the efficacy of this emerging immunotherapy, support the case for its integration into modern healthcare, and identify areas that require further exploration.

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Published In

cover image STEM Fellowship Journal
STEM Fellowship Journal
e-First
Pages: 1 - 4

History

Version of record online: 5 January 2023

Key Words

  1. neoantigens
  2. neoepitope vaccines
  3. cancer
  4. personal medicine
  5. immunotherapy

Authors

Affiliations

Ryan Ugovsek
St. Francis Xavier Secondary School, Mississauga, Ontario, Canada
Cecilia Lee
Department of Pathology and Laboratory Medicine, University of British Columbia, British Columbia, Ontario, Canada

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