Table of Contents

During a crisis, economies stagnate as uncertainty grows about the future state of the world. The financial crisis of 2008 led to a severe recession where the global economy halted for approximately two years, causing unemployment and poverty [1]. Coronavirus disease 2019 (COVID-19), which attacks the respiratory system [2], was first identified in Wuhan, China, in late December of 2019. Within a matter of months, it spread globally causing economies to shut down. As distinct as the financial crisis of 2008 may seem from the COVID-19 pandemic lockdowns, both have had devastating effects on national economies and industrial production, resulting in an overall decrease in air pollutant emissions such as carbon dioxide (CO₂) and nitrogen oxides (NO_x). Therefore, parallels can be made between air pollution levels during each crisis. Given air pollution rates increased after the financial crisis of 2008 [3], it is likely air pollution will also rise in the aftermath of the COVID-19 pandemic. This study aims to support this argument by analyzing air pollution trends outlined in the results of several published papers.

Syncope is characterized by the transient loss of consciousness followed by spontaneous recovery. The mechanism which underlies this condition is reduced blood flow to the brain [1]. Vasovagal syncope, often termed reflex syncope, is the most common type of syncope [1]. Vasovagal Syncope is caused by the abnormal autonomic reflex to certain stimuli such as pain, micturition/defecation, fear, seeing blood, etc., which results in vasodilation and often times, bradycardia [1].

As the Coronavirus Disease 2019 (COVID-19) pandemic evolved, information about the virus also accumulated. However, accompanied by the quick emergence of factual information was an even greater abundance of false information. For example, by March 2020, videos containing non-factual information on COVID-19 accounted for over one-quarter of the most viewed videos on YouTube — greatly exceeding the popularity of factual videos released by governments and health professionals [1]. The World Health Organization declared this massive flux of misinformation surrounding COVID-19 an “infodemic”, where it is hard to distinguish between factual and non-factual information [2].

A novel Coronavirus was identified in China as SARS-CoV-2 in December 2019 and was later declared a pandemic by the World Health Organization [1]. In most patients, COVID-19 presents with mild or moderate symptoms such as fever, cough, fatigue, and myalgia. However, around 10% of patients develop more severe symptoms such as pneumonia and multiorgan failure, which can result in death [1-2]. Until vaccines are widely available, the only way to reduce fatality rates is to treat affected patients with existing drugs and therapy options.

Countless lives have been saved with the advent of modern organ transplantation. However, the current shortage of compatible organ donors is limiting the life-saving potential of transplantation. According to the United Network for Organ Sharing, approximately 20 patients die each day in the United States while waiting for a transplant [1]. The discrepancy between supply and demand of organ donors is accentuated by a fundamental ethical dilemma associated with deceased organ donation: one person must die so that another may live [2]. The current viewpoint considers the viability of 3D bioprinting in microgravity as a solution to organ donor shortages. Current alternatives to deceased organ donation, including xenotransplantation and other state-of-the-art bioprinting techniques, are reviewed and compared to bioprinting in microgravity. The limitations of bioprinting within Earth’s gravitational field are also discussed, revealing the need for further research.

Zoonoses are human infections or diseases caused by disease spillover from vertebrate animals to people [1]. Spillover is the movement of pathogens from their normal host to a novel species [2]; this can occur through bodily fluids, bites, food, water, or contact with surfaces where infected animals have travelled [3]. Although some zoonoses remain established within populations and primarily affect only one person per spillover (classified as enzootic zoonoses—e.g., rabies), others can be transmitted between people and result in localized, or even global outbreaks [4]. Zoonoses account for over 60% of infectious diseases in humans [4] and can be caused by viruses, parasites, bacteria, or fungi. Of these, viral zoonoses prove to be of greatest detriment to the public on a widespread scale, as they are responsible for numerous epidemics and pandemics, including severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and the novel coronavirus (COVID-19) [5-7]. Research has also been conducted on different taxonomic orders of species, such as Carnivora — placental animals which obtain nutrients from flesh — and their viral spillover risk [11].